| ncRNA name | Rncr3 |
| ncRNA Category | lncRNA |
| ID | 268755 |
| Ensembl | ENSMUSG00000097545 |
| Synonyms | Mir124a-1hg; mir-3078; mir-124-1; A930011O12Rik |
| Disease name | diabetic retinopathy (DR) |
| Species | Mus musculus |
| Tissues/Cell_line | retinas |
| Methods | siRNA transfection, MTT assay, transwell assay, immunofluorescence staining |
| Expression pattern | up-regulated |
| Functional description | RNCR3 knockdown alleviates retinal vascular dysfunction in vivo, as shown by decreased acellular capillaries, decreased vascular leakage, and reduced inflammatory response. RNCR3 knockdown decreases retinal endothelial cell proliferation, and reduces cell migration and tube formation in vitro. RNCR3 regulates endothelial cell function through RNCR3/KLF2/miR-185-5p regulatory network. |
| PubMed ID | 27876564 |
| Year | 2017 |
| Title | RNCR3: A regulator of diabetes mellitus-related retinal microvascular dysfunction. |
| Drug-related ncRNA | NO |
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